Inventiva to Present the Latest Findings in its RORγ program at the 256th National Meeting of the American Chemical Society
August 01, 2018
Daix (France), August 1st, 2018 – Inventiva S.A. (“Inventiva” or the “Company”), a biopharmaceutical company developing innovative therapies in nonalcoholic steatohepatitis (NASH), Systemic Sclerosis (SSc) and mucopolysaccharidosis (MPS), today announced that Dominique Potin, Inventiva’s Principal Scientist of Medicinal Chemistry, will give a presentation on the Company’s ROR? program, entitled “Discovery of novel quinoline sulfonamide derivatives as potent, selective and orally active ROR;? inverse agonists;”, at the 256th National Meeting of the American Chemical Society being held on August 19-23, 2018 at the Boston Convention & Exhibition Center (BCEC) in Boston, Massachusetts.
Dr. Potin will present results from a high throughput screening of Inventiva’s library of 248,000 compounds using a GAL4 transactivation assay, which has led to the discovery of a new series of quinoline sulfonamides as potent orally inverse ROR? inhibitors. Dr. Potin will discuss the synthesis, structure activity relationship (SAR) and biological activity of these derivatives.
Inventiva and AbbVie, a global, research and development-based biopharmaceutical company, have entered into an agreement to discover and develop available ROR? inverse agonists which has led to the development of several orally available inverse ROR? inhibitors, showing activity in vivo both in a target engagement model and disease models. The most advanced compound, ABBV-157, has demonstrated a good safety profile during GLP- tox studies and has been selected to enter into Phase I clinical studies. Under the terms of the agreement, Inventiva is eligible for development and sales milestones as well as royalties on sales.
Dr. Potin commented: “Targeting the IL-17 pathway has become a very attractive approach for the treatment of immuno-inflammatory diseases in recent years. IL-17 antibodies such as secukinumab have validated the interest of blocking IL-17 secretion for such therapy. The nuclear receptor ROR?t is a critical element in the regulation of IL-17. It does indeed play a key role in the differentiation and development of Th17 cells that secrete IL-17A and other pro-inflammatory cytokines, like IL-17F and IL-22. Small molecule ROR?t inhibitors could be useful for the treatment of various diseases such as psoriasis or inflammatory bowel disease.”;
The details of the presentation are as follows:
Presentation Title: “Discovery of novel quinoline sulfonamide derivatives as potent, selective and orally active RORy inverse agonists”
Speaker: Dr. Dominique Potin, Principal Scientist of Medicinal Chemistry, Inventiva
Session Title:General Oral Session
Date:August 19, 2018
Time: 09:30 am (Eastern Time)
Location: MEDI 10, room 210A, Boston Convention & Exhibition Center (BCEC)
Lanifibranor, its lead product, is an anti-fibrotic treatment acting on the three alpha, gamma and delta PPARs (peroxisome proliferator-activated receptors), which play key roles in controlling the fibrotic process. Its anti-fibrotic action targets two initial indications with substantial unmet medical need: NASH, a severe and increasingly prevalent liver disease already affecting over 30 million people in the United States, and systemic sclerosis, a disease with a very high mortality rate and for which there is no approved treatment to date.
Inventiva is also developing a second clinical program with odiparcil (IVA 336) for the treatment of patients with mucopolysaccaridosis type VI (or Maroteaux-Lamy syndrome), a rare and severe gene disease affecting children. Odiparcil has also the potential to address other MPS types, characterized by the accumulation of chondroitin or dermatan sulfate (MPS I or Hurler/Sheie syndrome, MPS II or Hunter syndrome, MPS IVa or Morquio syndrome and MPS VII or Sly syndrome). Inventiva is also developing a portfolio of early research projects in the field of oncology.
Inventiva benefits from partnerships with world-leading research entities such as the Institut Curie in the field of oncology. Two strategic partnerships have also been established with world-class major pharmaceutical companies AbbVie and Boehringer Ingelheim in the fields of autoimmune diseases (specifically in psoriasis) and fibrosis respectively. These partnerships provide milestone payments to Inventiva upon the achievement of pre-clinical, clinical, regulatory and commercial milestones, in addition to royalties on the products resulting from the partnerships.
Inventiva employs over 100 employees and owns R&D facilities near Dijon, acquired from the international pharmaceutical group Abbott. The Company owns, a proprietary chemical library of over 240,000 molecules as well as integrated biology, chemistry, ADME and pharmacology platforms.
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